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For someone who cannot take an incretin-based medicine, a non-GLP-1 option may be the appropriate route

It helps regulate blood sugar by enhancing insulin secretion, reducing glucose production, and promoting satiety, making it effective for both glycemic control and weight reduction

"Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial." Eli Lilly and Company , 11 Dec

Don't panic if compounded semaglutide doesn't work straight away

It was developed to capture the fat-burning effects of HGH without the risks associated with growth or insulin signaling